EC	2.4.1.327
Accepted name:	aclacinomycin-T 2-deoxy-L-fucose transferase
Reaction:	dTDP-2-deoxy-β-L-fucose + aclacinomycin T = dTDP + aclacinomycin S
Glossary:	idarubicin = (7S,9S)-9-acetyl-7-(3-amino-2,3,6-trideoxy-β-L-lyxo-hexosyloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione aclacinomycin S = 7-O-(2-deoxy-α-L-fucosyl-(1→4)-rhodosaminyl)aklavinone aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone
Other name(s):	AknK
Systematic name:	dTDP-2-deoxy-β-L-fucose:7-(α-L-rhodosaminyl)aklavinone 2-deoxy-α-L-fucosyltransferase
Comments:	The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro.
References:	1.  Lu, W., Leimkuhler, C., Oberthur, M., Kahne, D. and Walsh, C.T. AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. Biochemistry 43 (2004) 4548–4558. [PMID: 15078101]
[EC 2.4.1.327 created 2014]